Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY

CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Warrants Related To debt arrangement	At The Market	Private Placement	Private Placement Pre-Funded Warrant	Follow On Offering	Common Stock	Common Stock At The Market	Common Stock Private Placement	Common Stock Private Placement Pre-Funded Warrant	Common Stock Follow On Offering	Additional Paid-In Capital	Additional Paid-In Capital Warrants Related To debt arrangement	Additional Paid-In Capital At The Market	Additional Paid-In Capital Private Placement	Additional Paid-In Capital Private Placement Pre-Funded Warrant	Additional Paid-In Capital Follow On Offering	Accumulated Other Comprehensive (Loss) Gain	Accumulated Deficit
Balance at Dec. 31, 2019	$ 79,184						$ 4					$ 372,139						$ 24	$ (292,983)
Balance (in shares) at Dec. 31, 2019							4,336,780
Exercise of stock options	1,076											1,076
Exercise of stock options, Shares							17,072
Vesting of restricted stock units, Shares							10,936
Issuance of common stock / preferred stock, warrants, net of issuance costs		$ 302	$ 11,919							$ 1			$ 302	$ 11,919
Issuance of common stock / preferred stock, warrants, net of issuance costs (in shares)								220,181		1,031,250
Issuance of shares under Employee Stock Purchase Plan	433											433
Issuance of shares under Employee Stock Purchase Plan, Shares							5,955
Exercise of warrants	9											9
Exercise of warrants, Shares							100
Stock-based compensation expense	10,939											10,939
Other comprehensive gain (loss)	(24)																	(24)
Net loss	(84,038)																		(84,038)
Balance at Dec. 31, 2020	90,553						$ 5					467,569							(377,021)
Balance (in shares) at Dec. 31, 2020							5,622,274
Exercise of stock options	157											157
Exercise of stock options, Shares							2,013
Vesting of restricted stock units, Shares							28,685
Issuance of common stock / preferred stock, warrants, net of issuance costs						$ 70,468					$ 1						$ 70,467
Issuance of common stock / preferred stock, warrants, net of issuance costs (in shares)											540,000
Issuance of shares under Employee Stock Purchase Plan	323											323
Issuance of shares under Employee Stock Purchase Plan, Shares							9,431
Stock-based compensation expense	10,354											10,354
Other comprehensive gain (loss)	(79)																	(79)
Net loss	(86,558)																		(86,558)
Balance at Dec. 31, 2021	$ 85,218						$ 6					548,870						(79)	(463,579)
Balance (in shares) at Dec. 31, 2021	6,202,403						6,202,403
Exercise of stock options, Shares	3,770						3,770
Vesting of restricted stock units	$ 1						$ 1
Vesting of restricted stock units, Shares							86,066
Issuance of common stock / preferred stock, warrants, net of issuance costs				$ 60,112	$ 70,753				$ 6						$ 60,106	$ 70,752
Issuance of common stock / preferred stock, warrants, net of issuance costs (in shares)									6,387,173
Issuance of shares under Employee Stock Purchase Plan	217											217
Issuance of shares under Employee Stock Purchase Plan, Shares							48,560
Issuance of shares in merger, net of issuance cost	65,332						$ 7					65,325
Issuance of shares in merger, net of issuance cost, Shares							7,546,014
Cancellation of fractional shares due to reverse stock split	(81)											(81)
Cancellation of fractional shares due to reverse stock split, shares							(10,870)
Stock-based compensation expense	11,410											11,410
Other comprehensive gain (loss)	181																	181
Net loss	(94,654)																		(94,654)
Balance at Dec. 31, 2022	$ 127,736						$ 20					$ 685,847						$ 102	$ (558,233)
Balance (in shares) at Dec. 31, 2022	20,263,116						20,263,116