Annual report pursuant to Section 13 and 15(d)

Nature of Business - Additional Information (Details)

Nature of Business - Additional Information (Details) $ / shares in Units, $ in Thousands				1 Months Ended	12 Months Ended
	Dec. 08, 2020 USD ($) $ / shares shares	Dec. 04, 2020 USD ($)	Apr. 09, 2019 USD ($) Agreement $ / shares shares	Nov. 30, 2019 USD ($) shares	Dec. 31, 2020 USD ($) $ / shares shares	Dec. 31, 2019 USD ($) $ / shares shares	Dec. 31, 2018 USD ($) shares
Stock Offering
Common stock, par value (in dollars per share) \| $ / shares					$ 0.001	$ 0.001
Warrants to purchase common stock \| shares					2,117,094	2,118,094
Transaction costs					$ 207
Number of underwriting agreements \| Agreement			2
Gross proceeds from public offerings			$ 70,000
Underwriting discounts and commissions and offering expenses			$ 5,000
Net Loss					84,038	$ 75,438	$ 62,279
Accumulated deficit					(377,021)	$ (292,983)
Cash equivalents and marketable securities					$ 174,000
Series A Convertible Preferred Stock
Stock Offering
Share price (in dollars per share) \| $ / shares					$ 6.57
Orsenix, LLC \| Asset Purchase Agreement
Stock Offering
Upfront fee payments		$ 12,000
Payments made upon achievement of regulatory milestone		6,000
Payments made upon achievement of commercial milestone		$ 10,000
Private Placement
Stock Offering
Warrants to purchase common stock \| shares					2,828,125
Gross proceeds of private placement	$ 90,500
Transaction costs	$ 400
Public Offering \| Class A Warrants
Stock Offering
Warrants, exercise price \| $ / shares			$ 8.625
Warrant expiration date			Oct. 10, 2022
Public Offering \| Common Stock Agreement \| Class A Warrants
Stock Offering
Warrants to purchase common stock \| shares			1,951,844
Share price (in dollars per share) \| $ / shares			$ 7.50
Public Offering \| Preferred Stock Agreement \| Series A Convertible Preferred Stock
Stock Offering
Shares issued \| shares			666
Public Offering \| Preferred Stock Agreement \| Class A Warrants
Stock Offering
Warrants to purchase common stock \| shares			166,500
Share price (in dollars per share) \| $ / shares			$ 7,500
Common Stock \| Private Placement
Stock Offering
Shares issued \| shares	10,312,500						144,505
Common stock, par value (in dollars per share) \| $ / shares	$ 0.001
Common Stock \| At Market Sales Facility
Stock Offering
Shares issued \| shares				180,787
Aggregate gross proceeds				$ 900
Common Stock \| Public Offering \| Common Stock Agreement
Stock Offering
Shares issued \| shares			8,667,333
Pre-Funded Warrant \| Private Placement
Stock Offering
Warrants to purchase common stock \| shares	1,000,000
Share price (in dollars per share) \| $ / shares	$ 8.00
Warrants \| Private Placement
Stock Offering
Share price (in dollars per share) \| $ / shares	$ 7.99
Warrants \| Private Placement \| Maximum
Stock Offering
Warrants to purchase common stock \| shares	2,828,125