Annual report pursuant to Section 13 and 15(d)

Income Taxes - Schedule of Reconciliation of U.S. Statutory Income Tax Rate to Effective Tax Rate - (Details)

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Income Taxes - Schedule of Reconciliation of U.S. Statutory Income Tax Rate to Effective Tax Rate - (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
Federal income tax computed at federal statutory tax rate 21.00% 21.00% 21.00%
State income tax, net of federal benefit 7.26% 6.12% 6.56%
Permanent items 3.60% (0.68%) (0.89%)
Federal and state research and development credits 5.79% 3.89% 4.79%
Other (1.41%) (0.88%) (0.77%)
Change in valuation allowance (36.24%) (29.45%) (30.73%)
Effective income tax rate     (0.04%)