Annual report pursuant to Section 13 and 15(d)

Nature of Business - Additional Information (Details)

Nature of Business - Additional Information (Details) $ / shares in Units, $ in Thousands					1 Months Ended		12 Months Ended
	Jan. 22, 2021 USD ($) $ / shares shares	Dec. 08, 2020 USD ($) $ / shares shares	Dec. 04, 2020 USD ($)	Apr. 09, 2019 USD ($) Agreement $ / shares shares	Jan. 31, 2021 USD ($) $ / shares shares	Nov. 30, 2019 USD ($) shares	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2020 USD ($) $ / shares shares	Dec. 31, 2019 USD ($) shares
Stock Offering
Gross proceeds from common stock								$ 11,896	$ 824
Common stock, par value (in dollars per share) \| $ / shares							$ 0.001	$ 0.001
Warrants to purchase common stock \| shares							2,117,094	2,117,094	2,118,094
Number of underwriting agreements \| Agreement				2
Gross proceeds from public offerings				$ 70,000
Underwriting discounts and commissions and offering expenses				$ 5,000
Net Loss							$ 86,558	$ 84,038	$ 75,438
Accumulated deficit							463,579	$ 377,021
Cash, cash equivalents and marketable securities, fair value							$ 143,400
Series A Convertible Preferred Stock
Stock Offering
Share price (in dollars per share) \| $ / shares							$ 6.57
Orsenix, LLC \| Asset Purchase Agreement
Stock Offering
Upfront fee payments			$ 12,000
Payments made upon achievement of regulatory milestone			6,000
Payments made upon achievement of commercial milestone			$ 10,000
Underwritten Public Offering
Stock Offering
Shares issued \| shares	5,400,000				5,400,000
Public offering price per share \| $ / shares	$ 14.00				$ 14.00
Gross proceeds from common stock	$ 75,600				$ 75,600
Underwriting discounts and commissions and other transaction expenses	$ 5,100				$ 5,100
Private Placement
Stock Offering
Warrants to purchase common stock \| shares							2,828,125	2,828,125
Gross proceeds of private placement		$ 90,500
Transaction costs		$ 400
Private Placement \| Common Stock
Stock Offering
Shares issued \| shares		10,312,500
Common stock, par value (in dollars per share) \| $ / shares		$ 0.001
Private Placement \| Pre-Funded Warrant
Stock Offering
Warrants to purchase common stock \| shares		1,000,000
Share price (in dollars per share) \| $ / shares		$ 8.00
Private Placement \| Warrants
Stock Offering
Share price (in dollars per share) \| $ / shares		$ 7.99
Private Placement \| Warrants \| Maximum
Stock Offering
Warrants to purchase common stock \| shares		2,828,125
At Market Sales Facility \| Common Stock
Stock Offering
Shares issued \| shares						180,787
Aggregate gross proceeds						$ 900
Public Offering \| Class A Warrants
Stock Offering
Warrants, exercise price \| $ / shares				$ 8.625
Warrant expiration date				Oct. 10, 2022
Public Offering \| Common Stock Agreement \| Class A Warrants
Stock Offering
Warrants to purchase common stock \| shares				1,951,844
Share price (in dollars per share) \| $ / shares				$ 7.50
Public Offering \| Preferred Stock Agreement \| Series A Convertible Preferred Stock
Stock Offering
Shares issued \| shares				666
Public Offering \| Preferred Stock Agreement \| Class A Warrants
Stock Offering
Warrants to purchase common stock \| shares				166,500
Share price (in dollars per share) \| $ / shares				$ 7,500
Public Offering \| Common Stock \| Common Stock Agreement
Stock Offering
Shares issued \| shares				8,667,333