Annual report pursuant to Section 13 and 15(d)

Commitments and Contingencies - Operating Leases - Additional Information (Details)

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Commitments and Contingencies - Operating Leases - Additional Information (Details)
$ in Thousands
 12 Months Ended
Jan. 08, 2019
ft²
Dec. 31, 2019
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Lessee Lease Description [Line Items]        
Operating lease, right-of-use asset     $ 14,104 $ 14,831
Operating lease liability, long-term     22,858 24,578
Operating lease obligation, current portion     $ 1,720 1,463
Accounting Standards Update 2016-02        
Lessee Lease Description [Line Items]        
Operating lease, right-of-use asset   $ 15,800    
Operating lease liability, long-term   15,800    
Net of tenant allowances expected to be received   $ 9,300    
Lease operating, discounted borrowing rate   9.30%    
Lease practical expedient   true    
Operating Lease, January 2019        
Lessee Lease Description [Line Items]        
Area of office and laboratory space leased | ft² 52,859      
Term of option to extend the lease     10 years  
Letter of credit outstanding     $ 3,100  
Operating Lease, January 2019 | Accounting Standards Update 2016-02        
Lessee Lease Description [Line Items]        
Operating lease liability, long-term     22,900 24,600
Operating lease obligation, current portion     $ 1,700 $ 1,400