Annual report pursuant to Section 13 and 15(d)

Accrued Expenses (Detail)

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Accrued Expenses (Detail) - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Accrued Liabilities Current [Abstract]    
External research and preclinical development $ 10,119 $ 5,875
Employee compensation and benefits 2,985 2,494
Professional fees 618 1,225
Facilities and other 171 134
Total accrued expenses $ 13,893 $ 9,728