Three Months Ended

March 31, 2018

June 30, 2018

September 30, 2018

December 31, 2018

Revenue

$

370

$

375

$

412

893

Operating expenses:

Research and development

11,116

11,082

12,856

15,128

General and administrative

4,075

3,841

3,876

4,372

Total operating expenses

15,191

14,923

16,732

19,500

Loss from operations

(14,821

)

(14,548

)

(16,320

)

(18,607

)

Other income, net

358

501

583

575

Net loss applicable to common stockholders

$

(14,463

)

$

(14,047

)

$

(15,737

)

(18,032

)

Net loss per share applicable to common stockholders - basic and diluted

$

(0.48

)

$

(0.43

)

$

(0.47

)

(0.54

)

Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted

30,335,164

32,892,712

33,653,479

33,694,756

Three Months Ended

March 31, 2017

June 30, 2017

September 30, 2017

December 31, 2017

Revenue

$

1,101

$

—

$

—

$

—

Operating expenses:

Research and development

9,628

10,041

10,447

11,780

General and administrative

3,086

3,472

3,593

3,740

Total operating expenses

12,714

13,513

14,040

15,520

Loss from operations

(11,613

)

(13,513

)

(14,040

)

(15,520

)

Other income, net

98

145

215

218

Net loss applicable to common stockholders

$

(11,515

)

$

(13,368

)

$

(13,825

)

$

(15,302

)

Net loss per share applicable to common stockholders - basic and diluted

$

(0.49

)

$

(0.52

)

$

(0.53

)

$

(0.58

)

Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted

23,393,448

25,584,147

26,259,216

26,316,550