Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies - Net Loss per Share (Details)

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Summary of Significant Accounting Policies - Net Loss per Share (Details) - shares
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Anti-dilutive securities                      
Total shares excluded from diluted net loss per share applicable to common stockholders                 3,732,643 2,846,668 2,548,320
Weighted-average number of common shares used in net loss per share applicable to common stockholders- basic and diluted 33,694,756 33,653,479 32,892,712 30,335,164 26,316,550 26,259,216 25,584,147 23,393,448 32,656,237 25,406,845 12,696,414
Stock options                      
Anti-dilutive securities                      
Total shares excluded from diluted net loss per share applicable to common stockholders                 3,732,643 2,846,668 2,543,435
Unvested Restricted Stock                      
Anti-dilutive securities                      
Total shares excluded from diluted net loss per share applicable to common stockholders                     4,885