Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Operating Leases - Additional Information (Details)

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Commitments and Contingencies - Operating Leases - Additional Information (Details)
$ in Thousands
 3 Months Ended
Jan. 08, 2019
ft²
Mar. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Lessee Lease Description [Line Items]      
Operating lease, right-of-use asset   $ 13,900 $ 14,104
Operating lease liability, short term   1,789 1,720
Operating lease liability, long-term   22,378 $ 22,858
Accounting Standards Update 2016-02      
Lessee Lease Description [Line Items]      
Operating lease, right-of-use asset   15,800  
Operating lease liability, long-term   $ 15,800  
Lease operating, discounted borrowing rate   9.30%  
Net of tenant allowances expected to be received   $ 9,300  
Lease practical expedient   true  
HQ Lease      
Lessee Lease Description [Line Items]      
Area of office and laboratory space leased | ft² 52,859    
Term of option to extend the lease   10 years  
Letter of credit outstanding   $ 3,100  
HQ Lease | Accounting Standards Update 2016-02      
Lessee Lease Description [Line Items]      
Operating lease liability, short term   1,800  
Operating lease liability, long-term   $ 22,400