Annual report pursuant to Section 13 and 15(d)

Selected Quarterly Financial Data (unaudited) - (Details)

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Selected Quarterly Financial Data (unaudited) - (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Quarterly Financial Information Disclosure [Abstract]                      
Revenue $ 508 $ 558 $ 462 $ 454 $ 893 $ 412 $ 375 $ 370 $ 1,982 $ 2,050 $ 1,101
Operating expenses:                      
Research and development 14,277 15,931 15,475 12,562 15,128 12,856 11,082 11,116 58,245 50,182 41,896
General and administrative 6,402 5,016 5,195 4,865 4,372 3,876 3,841 4,075 21,478 16,164 13,891
Total operating expenses 20,679 20,947 20,670 17,427 19,500 16,732 14,923 15,191 79,723 66,346 55,787
Loss from operations (20,171) (20,389) (20,208) (16,973) (18,607) (16,320) (14,548) (14,821) (77,741) (64,296) (54,686)
Other income, net 442 596 753 512 575 583 501 358 2,303 2,017 676
Net loss applicable to common stockholders $ (19,729) $ (19,793) $ (19,455) $ (16,461) $ (18,032) $ (15,737) $ (14,047) $ (14,463) $ (75,438) $ (62,279) $ (54,010)
Net loss per share applicable to common stockholders - basic and diluted $ (0.46) $ (0.47) $ (0.47) $ (0.49) $ (0.54) $ (0.47) $ (0.43) $ (0.48) $ (1.88) $ (1.91) $ (2.13)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted 42,885,208 42,439,338 41,673,275 33,766,333 33,694,756 33,653,479 32,892,712 30,335,164 40,222,182 32,656,237 25,406,845