Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies - Net Loss per Share (Details)

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Summary of Significant Accounting Policies - Net Loss per Share (Details) - shares
3 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Anti-dilutive securities                      
Total shares excluded from diluted net loss per share applicable to common stockholders                 7,852,873 3,732,643 2,846,668
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted 42,885,208 42,439,338 41,673,275 33,766,333 33,694,756 33,653,479 32,892,712 30,335,164 40,222,182 32,656,237 25,406,845
Stock options                      
Anti-dilutive securities                      
Total shares excluded from diluted net loss per share applicable to common stockholders                 4,618,421 3,732,643 2,846,668
Unvested Restricted Stock Unit                      
Anti-dilutive securities                      
Total shares excluded from diluted net loss per share applicable to common stockholders                 1,116,358    
Warrants                      
Anti-dilutive securities                      
Total shares excluded from diluted net loss per share applicable to common stockholders                 2,118,094