Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF CASH FLOWS

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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Operating activities      
Net loss $ (54,010) $ (47,743) $ (29,818)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 1,527 1,273 602
Loss on disposal of assets   4 17
Stock-based compensation expense 4,419 4,234 3,233
Net amortization of premiums and discounts on marketable securities (102) 6  
Changes in operating assets and liabilities:      
Prepaid expenses and other current assets 131 (508) (390)
Accounts receivable 867 (317)  
Other long-term assets (365) (482)  
Restricted cash     (413)
Accounts payable 141 (404) 2,022
Accrued expenses 3,533 3,685 1,663
Deferred revenue (550)    
Deferred rent and lease incentive (320) (284) 54
Net cash used in operating activities (44,729) (40,536) (23,030)
Investing activities      
Purchases of property and equipment (821) (2,322) (1,176)
Purchases of marketable securities (41,770) (25,020)  
Sales or maturities of marketable securities 27,000    
Net cash used in investing activities (15,591) (27,342) (1,176)
Financing activities      
Payments on capital lease obligations (168) (135) (50)
Proceeds from issuance of common stock through employee benefit plans 1,799 395 392
Proceeds from issuance of convertible preferred stock, net of issuance costs   39,813  
Proceeds from issuance of common stock, net of issuance costs 32,306 50,484 (620)
Net cash provided by (used in) financing activities 33,937 90,557 (278)
(Decrease) increase in cash and cash equivalents (26,383) 22,679 (24,484)
Cash and cash equivalents, Beginning of period 58,588 35,909 60,393
Cash and cash equivalents, End of period 32,205 58,588 35,909
Supplemental disclosure of cash flow information:      
Cash paid for interest 9 19 18
Non-cash investing and financing activities      
Conversion of convertible preferred stock into common stock   82,013  
Property and equipment received but unpaid as of period end 143 349 1,359
Assets acquired under capital lease   $ 17 389
Assets acquired through lease incentive     1,612
Offering costs incurred but unpaid as of period end $ 13   $ 1,280