Annual report pursuant to Section 13 and 15(d)

Selected Quarterly Financial Data (unaudited) - (Details)

v3.6.0.2
Selected Quarterly Financial Data (unaudited) - (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Selected Quarterly Financial Information                      
Revenue $ 317           $ 317   $ 317 $ 317  
Operating expenses:                      
Research and development 8,443 $ 11,584 $ 9,525 $ 8,265 $ 8,378 $ 6,866 5,428 $ 3,736 37,817 24,408 $ 10,923
General and administrative 2,919 2,633 2,540 2,371 2,311 1,598 984 836 10,463 5,729 2,512
Total operating expenses 11,362 14,217 12,065 10,636 10,689 8,464 6,412 4,572 48,280 30,137 13,435
Loss from operations (11,045) (14,217) (12,065) (10,636) (10,689) (8,464) (6,095) (4,572) (47,963) (29,820) (13,435)
Other income (expense), net 80 48 44 48     (2) 4 220 2 4
Net loss (10,965) (14,169) (12,021) (10,588) (10,689) (8,464) (6,097) (4,568) (47,743) (29,818) (13,431)
Accrued dividends on preferred stock   (121) (1,823) (1,737) (1,244) (1,243) (1,230) (1,217) (3,681) (4,934) (2,211)
Net loss applicable to common stockholders $ (10,965) $ (14,290) $ (13,844) $ (12,325) $ (11,933) $ (9,707) $ (7,327) $ (5,785) $ (51,424) $ (34,752) $ (15,642)
Net loss per share applicable to common stockholders - basic and diluted $ (0.47) $ (0.65) $ (5.42) $ (5.15) $ (5.14) $ (4.51) $ (4.16) $ (3.44) $ (4.05) $ (17.55) $ (10.26)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted 23,374,734 22,012,743 2,553,146 2,394,470 2,320,781 2,150,274 1,761,457 1,682,690 12,696,414 1,980,286 1,525,018