Selected Quarterly Financial Data (unaudited) (Tables)

12 Months Ended

Dec. 31, 2016


	Three Months Ended
	March 31, 2016		June 30, 2016		September 30, 2016		December 31, 2016

Revenue	$	—	$	—	$	—	$	317
Operating expenses:
Research and development		8,265		9,525		11,584		8,443
General and administrative		2,371		2,540		2,633		2,919
Total operating expenses		10,636		12,065		14,217		11,362
Loss from operations		(10,636)		(12,065)		(14,217)		(11,045)

Other income, net		48		44		48		80
Net loss	$	(10,588)	$	(12,021)	$	(14,169)	$	(10,965)
Accrued dividends on preferred stock		(1,737)		(1,823)		(121)		—
Net loss applicable to common stockholders	$	(12,325)	$	(13,844)	$	(14,290)	$	(10,965)

Net loss per share applicable to common stockholders - basic and diluted	$	(5.15)	$	(5.42)	$	(0.65)	$	(0.47)

Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted		2,394,470		2,553,146		22,012,743		23,374,734


	Three Months Ended
	March 31, 2015		June 30, 2015		September 30, 2015		December 31, 2015

Revenue	$	—	$	317	$	—	$	—
Operating expenses:
Research and development		3,736		5,428		6,866		8,378
General and administrative		836		984		1,598		2,311
Total operating expenses		4,572		6,412		8,464		10,689
Loss from operations		(4,572)		(6,095)		(8,464)		(10,689)

Other income (expense), net		4		(2)		—		—
Net loss	$	(4,568)	$	(6,097)	$	(8,464)	$	(10,689)
Accrued dividends on preferred stock		(1,217)		(1,230)		(1,243)		(1,244)
Net loss applicable to common stockholders	$	(5,785)	$	(7,327)	$	(9,707)	$	(11,933)

Net loss per share applicable to common stockholders - basic and diluted	$	(3.44)	$	(4.16)	$	(4.51)	$	(5.14)

Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted		1,682,690		1,761,457		2,150,274		2,320,781