Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS??? EQUITY (DEFICIT)

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CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS’ EQUITY (DEFICIT) - USD ($)
$ in Thousands
Common Stock
Series A convertible preferred stock
Common Stock
Series B convertible preferred stock
Common Stock
Additional Paid‑In Capital
Series A convertible preferred stock
Additional Paid‑In Capital
Series B convertible preferred stock
Additional Paid‑In Capital
Accumulated Other Comprehensive Loss
Accumulated Deficit
Series A convertible preferred stock
Series B convertible preferred stock
Total
Balance at Dec. 31, 2014     $ 1     $ 1,922   $ (23,695)     $ (21,772)
Balance (in shares) at Dec. 31, 2014     1,640,009                
Increase (Decrease) in Stockholders' Equity (Deficit)                      
Exercise of stock options and vesting of restricted stock awards     $ 1     392         393
Exercise of stock options and vesting of restricted stock awards (in shares)     723,009                
Stock-based compensation expense           3,233         3,233
Net loss               (29,818)     (29,818)
Balance at Dec. 31, 2015     $ 2     5,547   (53,513)     (47,964)
Balance (in shares) at Dec. 31, 2015     2,363,018                
Balance at Dec. 31, 2014                 $ 29,015 $ 52,998  
Balance (in shares) at Dec. 31, 2014                 30,350,000 16,893,931  
Balance at Dec. 31, 2015                 $ 29,015 $ 52,998  
Balance (in shares) at Dec. 31, 2015                 30,350,000 16,893,931  
Increase (Decrease) in Stockholders' Equity (Deficit)                      
Conversion of convertible preferred stock into common stock $ 8 $ 8   $ 29,007 $ 92,784       $ 29,015 $ 92,792  
Conversion of convertible preferred stock into common stock (in shares) 8,093,326 7,895,474                  
Issuance of common stock, net of issuance costs     $ 5     49,877         49,882
Issuance of common stock, net of costs and fees (in shares)     4,600,000                
Exercise of stock options and vesting of restricted stock awards           395         395
Exercise of stock options and vesting of restricted stock awards (in shares)     429,070                
Stock-based compensation expense           4,234         4,234
Other comprehensive loss             $ (9)       (9)
Net loss               (47,743)     (47,743)
Balance at Dec. 31, 2016     $ 23     181,844 (9) (101,256)     $ 80,602
Balance (in shares) at Dec. 31, 2016     23,380,888               23,380,888
Increase (Decrease) in Temporary Equity                      
Issuance of convertible preferred stock, net of issuance costs                   $ 39,794  
Issuance of convertible preferred stock, net of issuance costs (in shares)                   12,714,150  
Conversion of convertible preferred stock into common stock                 $ (29,015) $ (92,792)  
Conversion of convertible preferred stock into common stock (in shares)                 (30,350,000) (29,608,081)  
Issuance of common stock, net of issuance costs     $ 3     32,544         $ 32,547
Issuance of common stock, net of costs and fees (in shares)     2,592,591                
Exercise of stock options and vesting of restricted stock awards           1,799         1,799
Exercise of stock options and vesting of restricted stock awards (in shares)     449,896                
Stock-based compensation expense           4,419         4,419
Other comprehensive loss             (33)       (33)
Net loss               (54,010)     (54,010)
Balance at Dec. 31, 2017     $ 26     $ 220,606 $ (42) $ (155,266)     $ 65,324
Balance (in shares) at Dec. 31, 2017     26,423,375               26,423,375