Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Operating Leases (Details)

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Commitments and Contingencies - Operating Leases (Details)
1 Months Ended 3 Months Ended 12 Months Ended
Mar. 31, 2015
ft²
Mar. 31, 2017
USD ($)
Mar. 31, 2016
USD ($)
Dec. 31, 2016
USD ($)
Operating leases        
Area of office and laboratory space leased | ft² 21,488      
Term of option to extend the lease   5 years    
Rent expense   $ 221,000 $ 220,000 $ 882,000
Restricted Cash        
Operating leases        
Original letter of credit   $ 483,000   $ 483,000