Annual report pursuant to Section 13 and 15(d)

Document and Entity Information

Document and Entity Information - USD ($)
12 Months Ended
Dec. 31, 2022
Feb. 27, 2023
Jun. 30, 2022
Cover [Abstract]      
Entity Registrant Name SYROS PHARMACEUTICALS, INC.    
Trading Symbol SYRS    
Entity Central Index Key 0001556263    
Document Type 10-K    
Document Period End Date Dec. 31, 2022    
Amendment Flag false    
Current Fiscal Year End Date --12-31    
Entity Well-known Seasoned Issuer No    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Filer Category Non-accelerated Filer    
Entity Common Stock, Shares Outstanding   20,300,419  
Entity Public Float     $ 55,740,050
Document Fiscal Year Focus 2022    
Document Fiscal Period Focus FY    
Entity Small Business true    
Entity Emerging Growth Company false    
Entity Shell Company false    
Entity File Number 001-37813    
Entity Tax Identification Number 45-3772460    
Entity Address, Address Line One 35 CambridgePark Drive    
Entity Address, Address Line Two 4th Floor    
Entity Address, City or Town Cambridge    
Entity Address, State or Province MA    
Entity Address, Postal Zip Code 02140    
City Area Code 617    
Local Phone Number 744-1340    
Document Annual Report true    
Document Transition Report false    
Entity Interactive Data Current Yes    
Entity Incorporation, State or Country Code DE    
Title of 12(b) Security Common Stock, $0.001 par value    
Security Exchange Name NASDAQ    
ICFR Auditor Attestation Flag false    
Auditor Firm ID 42    
Auditor Name Ernst & Young LLP    
Auditor Location Boston, Massachusetts