Quarterly report pursuant to Section 13 or 15(d)

Accrued Expenses (Detail)

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Accrued Expenses (Detail) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Accrued Liabilities Current [Abstract]    
External research and preclinical development $ 6,782 $ 10,119
Employee compensation and benefits 1,331 2,985
Professional fees 787 618
Facilities and other 186 171
Total accrued expenses $ 9,086 $ 13,893