Annual report pursuant to Section 13 and 15(d)

Stock-Based Payments - Stock-Based Compensation Expense (Details)

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Stock-Based Payments - Stock-Based Compensation Expense (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Stock-based compensation expense for stock options and restricted common stock granted      
Stock-based compensation expense $ 4,234 $ 3,233 $ 937
Unrecognized compensation cost related to non-vested stock options and unvested restricted common stock granted to employees $ 8,800    
Weighted average period over which future compensation cost is expected to be recognized for awards granted to employees 3 years    
Unrecognized compensation cost related to non-vested stock options granted to non-employees $ 800    
Research and development      
Stock-based compensation expense for stock options and restricted common stock granted      
Stock-based compensation expense 2,980 2,733 830
General and administrative      
Stock-based compensation expense for stock options and restricted common stock granted      
Stock-based compensation expense $ 1,254 $ 500 $ 107