Know all by these presents, that the undersigned hereby makes,
constitutes and appoints each of Nancy Simonian, Joseph Ferra and Gerald Quirk,
signing singly and each acting individually, as the undersigned's true and
lawful attorney-in-fact with full power and authority as hereinafter described

      (1)      execute for and on behalf of the undersigned, in the
               undersigned's capacity as an officer and/or director of Syros
               Pharmaceuticals, Inc. (the "Company"), Forms 3, 4, and 5
               (including any amendments thereto) in accordance with Section
               16(a) of the Securities Exchange Act of 1934 and the rules
               thereunder (the "Exchange Act");

      (2)      do and perform any and all acts for and on behalf of the
               undersigned which may be necessary or desirable to prepare,
               complete and execute any such Form 3, 4, or 5, prepare, complete
               and execute any amendment or amendments thereto, and timely
               deliver and file such form with the United States Securities and
               Exchange Commission (the "SEC") and any stock exchange or similar
               authority, including without limitation the filing of a Form ID
               or any other application materials to enable the undersigned to
               gain or maintain access to the Electronic Data Gathering,
               Analysis and Retrieval system of the SEC;

      (3)      seek or obtain, as the undersigned's representative and on the
               undersigned's behalf, information regarding transactions in the
               Company's securities from any third party, including brokers,
               employee benefit plan administrators and trustees, and the
               undersigned hereby authorizes any such person to release any such
               information to such attorney-in-fact and approves and ratifies
               any such release of information; and

      (4)      take any other action of any type whatsoever in connection with
               the foregoing which, in the opinion of such attorney-in-fact, may
               be of benefit to, in the best interest of, or legally required
               by, the undersigned, it being understood that the documents
               executed by such attorney-in-fact on behalf of the undersigned
               pursuant to this Power of Attorney shall be in such form and
               shall contain such terms and conditions as such attorney-in-fact
               may approve in such attorney-in-fact's discretion.

      The undersigned hereby grants to each such attorney-in-fact full power
and authority to do and perform any and every act and thing whatsoever
requisite, necessary, or proper to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as the
undersigned might or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming all that such
attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall
lawfully do or cause to be done by virtue of this power of attorney and the
rights and powers herein granted.  The undersigned acknowledges that the
foregoing attorneys-in-fact, in serving in such capacity at the request of the
undersigned, are not assuming nor relieving, nor is the Company assuming nor
relieving, any of the undersigned's responsibilities to comply with Section 16
of the Exchange Act.  The undersigned acknowledges that neither the Company nor
the foregoing attorneys-in-fact assume (i) any liability for the undersigned's
responsibility to comply with the requirement of the Exchange Act, (ii) any
liability of the undersigned for any failure to comply with such requirements,
or (iii) any obligation or liability of the undersigned for profit disgorgement
under Section 16(b) of the Exchange Act.

      This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4, and 5 with respect to the
undersigned's holdings of and transactions in securities issued by the Company,
unless earlier revoked by the undersigned in a signed writing delivered to the
foregoing attorneys-in-fact.

      IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to
be executed as of this 19th day of December, 2019.


 /s/ Mark J. Alles
Mark J. Alles
Print Name