Exhibit 107

Calculation of Filing Fee Tables

Form S-8

(Form Type)

Syros Pharmaceuticals, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1—Newly Registered Securities

 

               

Security

Type

 

Security Class

Title

  Fee
Calculation
Rule
  Amount
Registered (1)
  Proposed
Maximum
Offering
Price Per
Unit
 

Maximum
Aggregate

Offering

Price

 

Fee

Rate

  Amount of
Registration
Fee
               
Equity  

Common

Stock,

$0.001 par

value per

share

  Other   952,631 (2)   $3.63 (3)   $3,458,050.53 (3)  

$110.20 per

$1,000,000

  $381.08
         
Total Offering Amounts     $3,458,050.53     $381.08
         
Total Fee Offsets         $—
         
Net Fee Due               $381.08

 

(1)

In accordance with Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), this registration statement shall be deemed to cover any additional securities that may from time to time be offered or issued to prevent dilution resulting from stock splits, stock dividends or similar transactions.

(2)

Consists of (i) 202,631 shares issuable under the 2016 Employee Stock Purchase Plan pursuant to such plan’s evergreen provision and (ii) 750,000 shares issuable under the 2022 Inducement Stock Incentive Plan, as amended.

(3)

Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act, and based upon the average of the high and low prices of the registrant’s common stock as reported on the Nasdaq Global Select Market on February 27, 2023.