Exhibit 107

Calculation of Filing Fee Tables

Form S-3

(Form Type)

Syros Pharmaceuticals, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered and Carry Forward Securities

 

                         
      Security
Type
  

Security

Class

Title

  

Fee

Calculation
or Carry
Forward
Rule

   Amount
Registered
   Proposed
Maximum
Offering
Price Per
Unit
   Maximum
Aggregate
Offering
Price
   Fee
Rate
   Amount of
Registration
Fee
  

Carry
Forward

Form
Type

  

Carry
Forward
File

Number

  

Carry
Forward

Initial
Effective
Date

   Filing Fee
Previously
Paid In
Connection
with Unsold
Securities to
be Carried
Forward
 
Newly Registered Securities
                         

Fees to Be

Paid

   Equity     Common Stock, $0.001 par value per share    Other    27,627,824(1)     $6.06(2)     $167,424,614(2)     0.00011020     $18,450.20                     
                         

Fees

Previously 

Paid

   —      —      —      —      —      —      —      —                      
 
Carry Forward Securities
                         

Carry

Forward

Securities

   —      —      —      —      —      —      —      —      —      —      —      —  
                   
     Total Offering Amounts         $167,424,614(2)     —      $18,450.20                     
                   
     Total Fees Previously Paid                   —                      
                   
     Total Fee Offsets                   —                      
                   
     Net Fee Due                   $18,450.20                     

 

(1)

The shares of common stock will be offered for resale by the selling stockholders pursuant to the prospectus contained in the registration statement to which this exhibit is attached. The registration statement registers the resale of an aggregate of 27,627,824 shares of the Registrant’s common stock, which consists of (i) 6,387,173 outstanding shares of common stock, (ii) 7,426,739 shares of common stock issuable upon the exercise of outstanding pre-funded warrants and (iii) 13,813,912 shares of common stock issuable upon the exercise of outstanding warrants (or issuable upon exercise of pre-funded warrants to purchase shares of common stock that are issuable to holders of warrants upon exercise of such warrants for pre-funded warrants in lieu of common stock). Pursuant to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), the shares of common stock being registered hereunder include such indeterminate number of shares of common stock as may be issuable upon stock splits, stock dividends, or other distribution, recapitalization or similar events.

 

(2)

This estimate is made pursuant to Rule 457(c) of the Securities Act solely for purposes of calculating the registration fee. The price per share and aggregate offering price are based upon the average of the high and low prices of the Registrant’s common stock on October 12, 2022, as reported on the Nasdaq Global Select Market.